Findings

What do systematic reviews say?

2 questions · 2 findings · 2 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 50%Low 0 · 0%Moderate 1 · 50%High 0 · 0%

Treatment withdrawal · people with drug‐resistant generalised tonic‐clonic seizures

It is very uncertain whether add‐on lamotrigine changes treatment withdrawal compared with placebo (very low certainty).

1 finding from 1 review

Lamotrigine add‐on therapy for drug‐resistant generalised tonic‐clonic seizures 2020 · Cochrane Headline outcomes only
RR 1.2 [0.72, 1.99]
2 studies · 270 participants
Very low

Treatment withdrawal · people with drug‐resistant focal epilepsy

Summary of findings: lamotrigine showed no clear difference in treatment withdrawal compared with placebo (moderate certainty).

1 finding from 1 review

Lamotrigine add‐on therapy for drug‐resistant focal epilepsy 2023 · Cochrane Headline outcomes only
RR 1.11 [0.91, 1.37]
14 studies · 1806 participants
Moderate