Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews · Neonatal

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 2 · 100%High 0 · 0%

HFNC vs nasal intermittent positive pressure ventilation

Treatment failure within 72 hours of trial entry · preterm infants requiring primary respiratory support

Nasal high flow showed no clear difference in treatment failure within 72 hours of trial entry compared with nasal intermittent positive pressure ventilation (moderate certainty).

1 finding from 1 review

Nasal high flow therapy for primary respiratory support in preterm infants 2023 · Cochrane Headline outcomes only
RR 1.27 [0.9, 1.79]
4 studies · 343 participants
Moderate

HFNC vs continuous positive airway pressure (CPAP)

Treatment failure within 72 hours of trial entry · preterm infants requiring primary respiratory support

Nasal high flow probably leads to higher treatment failure within 72 hours of trial entry compared with continuous positive airway pressure (moderate certainty).

1 finding from 1 review

Nasal high flow therapy for primary respiratory support in preterm infants 2023 · Cochrane Headline outcomes only
RR 1.7 [1.41, 2.06]
9 studies · 2042 participants
Moderate