Findings

What do systematic reviews say?

3 questions · 3 findings · 2 reviews · Neonatal

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 66.7%Low 1 · 33.3%Moderate 0 · 0%High 0 · 0%

Treatment failure To discharge · newborn infants with opioid withdrawal

It is very uncertain whether clonidine and opioid changes treatment failure To discharge compared with opioid alone (very low certainty).

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
RR 0.09 [0.01, 1.59]
1 study · 80 participants
Very low

Treatment failure To discharge · newborn infants with opioid withdrawal

It is very uncertain whether clonidine and opioid changes treatment failure To discharge compared with phenobarbital and opioid (very low certainty).

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
RR 2.27 [0.98, 5.25]
2 studies · 93 participants
Very low

Treatment failure To discharge · newborn infants with opioid withdrawal

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 31 participants
Low