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What do systematic reviews say?

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Evidence found and GRADE certainty

6 questions · 6 findings · 3 reviews · Headline outcomes only

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No studies found 2 · 33.3%GRADE not reported 0 · 0%Very low 0 · 0%Low 4 · 66.7%Moderate 0 · 0%High 0 · 0%

Peginterferon plus ribavirin vs non‐pegylated interferon plus ribavirin

Discontinuation of medication due to adverse events · people with chronic hepatitis C

Peginterferon plus ribavirin showed no clear difference in adverse events leading to treatment discontinuation compared with non‐pegylated interferon plus ribavirin (low certainty).

1 finding from 1 review

Peginterferon alpha‐2a vs peginterferon alpha‐2b

Discontinuation of medication due to adverse events · people with chronic hepatitis C

Peginterferon alpha‐2a showed no clear difference in adverse events leading to treatment discontinuation Number of events compared with peginterferon alpha‐2b (low certainty).

1 finding from 1 review