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Evidence found and GRADE certainty

4 questions · 4 findings · 3 reviews · Epilepsy

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Rufinamide plus ASMs vs other ASM plus ASMs

Number of adverse events requiring discontinuation of treatment ‐ not reported · Lennox‐Gastaut syndrome, any age

Rufinamide plus ASMs showed no clear difference in number of participants with treatment‐emergent adverse events… compared with other ASM plus ASMs (low certainty).

1 finding from 1 review

Clonazepam vs carbamazepine

Proportion of participants with treatment‐emergent adverse events (TEAEs) ‐ Leading to discontinuation during the treatment period № of participants: 36 (1 RCT) · people with newly diagnosed epilepsy

It is very uncertain whether clonazepam changes proportion of participants with treatment‐emergent adverse events… compared with carbamazepine (very low certainty).

1 finding from 1 review

Clobazam vs phenytoin

Retention [ · drug‐naïve people with focal or generalized seizures with solitary cysticercus granuloma

Clobazam may leads to higher retention at 6 months (measured by the number of treatment failures… compared with phenytoin (low certainty).

1 finding from 1 review