Findings

What do systematic reviews say?

3 questions · 3 findings · 3 reviews · Haematology

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 3 · 100%High 0 · 0%

Cytarabine plus high‐dose methotrexate vs high‐dose methotrexate alone

Treatment‐related mortality · patients with primary CNS lymphoma

Cytarabine plus high‐dose methotrexate showed no clear difference in treatment‐related mortality compared with high‐dose methotrexate alone (moderate certainty).

1 finding from 1 review

Role of chemotherapy additional to high‐dose methotrexate for primary central nervous system lymphoma (PCNSL) 2012 · Cochrane Headline outcomes only
RR 3.08 [0.33, 28.32]
1 study · 79 participants
Moderate

Intervention not reported

Treatment‐related mortality · Adult patients with follicular lymphoma

The intervention showed no clear difference in treatment‐related mortality (moderate certainty).

1 finding from 1 review

High‐dose therapy with autologous stem cell transplantation versus chemotherapy or immuno‐chemotherapy for follicular… 2012 · Cochrane Headline outcomes only
RR 1.28 [0.25, 6.61]
4 studies · 941 participants
Moderate

Intervention not reported

Treatment‐related mortality ‐ overall analysis (at 3 years) · Patients with refractory/relapsed Hodgkin lymphoma

The intervention showed no clear difference in treatment‐related mortality ‐ overall analysis (at 3 years) (moderate certainty).

1 finding from 1 review

High‐dose chemotherapy followed by autologous stem cell transplantation for patients with relapsed/refractory Hodgkin… 2013 · Cochrane Headline outcomes only
RR 0.61 [0.16, 2.22]
2 studies · 157 participants
Moderate