Findings

What do systematic reviews say?

2 questions · 2 findings · 2 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 1 · 50%High 1 · 50%

Summary of findings: Aminosalicylates vs placebo

Acute and late GI toxicity (grade 2+) · People undergoing pelvic radiotherapy for urological, gynaecological or colorectal cancer

Summary of findings: Aminosalicylates probably leads to higher acute and late GI toxicity (grade 2+) compared with placebo (moderate certainty).

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
RR 1.02 [1.22, 1.45]
2 studies · 143 participants
Moderate

beta‐lactam monotherapy vs beta‐lactam (cloxacillin) plus aminoglycoside (gentamicin)

Any nephrotoxicity ‐ Ag dosing regimen (Copy) · people with cancer who have febrile neutropenia

beta‐lactam monotherapy leads to lower any nephrotoxicity ‐ Ag dosing regimen (Copy) compared with beta‐lactam‐aminoglycoside combination therapy (high certainty).

1 finding from 1 review

Beta‐lactam versus beta‐lactam‐aminoglycoside combination therapy in cancer patients with neutropenia 2013 · Cochrane Headline outcomes only
RR 0.45 [0.35, 0.57]
39 studies · 6608 participants
High