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What do systematic reviews say?

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Evidence found and GRADE certainty

8 questions · 8 findings · 5 reviews · Hypertension

No studies found 3 · 37.5%GRADE not reported 0 · 0%Very low 1 · 12.5%Low 3 · 37.5%Moderate 1 · 12.5%High 0 · 0%

Lower blood pressure targets vs standard blood pressure targets

Total serious adverse events · cardiovascular disease with high blood pressure

Lower blood pressure targets showed no clear difference in total serious adverse events compared with standard blood pressure targets (low certainty).

1 finding from 1 review

Antihypertensive drug therapy vs placebo or no treatment

Total serious adverse events · adults (18 years of age or older) with hypertension‐induced left ventricular hypertrophy

It is very uncertain whether antihypertensive therapy changes total serious adverse events compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Intervention not reported

Total serious adverse events Systolic targets · Diabetes Mellitus with elevated blood pressure

The intervention showed no clear difference in total serious adverse events Systolic targets (low certainty).

1 finding from 1 review

First‐line thiazides vs calcium channel blockers

Total serious adverse events Duration: 1.75 to 3 years · patients with hypertension

First‐line thiazides showed no clear difference in total serious adverse events Duration: 1.75 to 3 years compared with first‐line calcium channel blockers (low certainty).

1 finding from 1 review