Findings

What do systematic reviews say?

9 questions · 9 findings · 6 reviews · Hypertension

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 22.2%Low 4 · 44.4%Moderate 2 · 22.2%High 1 · 11.1%

Lower blood pressure targets vs standard blood pressure targets

Total mortality · cardiovascular disease with high blood pressure

Lower blood pressure targets showed no clear difference in total mortality compared with standard blood pressure targets (moderate certainty).

1 finding from 1 review

Blood pressure targets for the treatment of people with hypertension and cardiovascular disease 2022 · Cochrane Headline outcomes only
RR 1.05 [0.91, 1.23]
7 studies · 9595 participants
Moderate

Aspirin vs placebo

Total mortality · adults with hypertension (patients with atrial fibrillation, congestive heart failure, pre‐eclampsia or pulmonary hypertension were…

Aspirin showed no clear difference in total mortality compared with placebo (low certainty).

1 finding from 1 review

Antiplatelet agents and anticoagulants for hypertension 2022 · Cochrane Headline outcomes only
OR 0.97 [0.87, 1.08]
3 studies · 35794 participants
Low

Orlistat vs placebo

Total mortality · Men and non‐pregnant women ≥ 18 years old with essential hypertension

1 finding from 1 review

Long‐term effects of weight‐reducing drugs in people with hypertension 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 1488 participants
Low

Naltrexone/bupropion vs placebo

Total mortality · Men and non‐pregnant women ≥ 18 years old with essential hypertension

Naltrexone/bupropion showed no clear difference in total mortality compared with placebo (moderate certainty).

1 finding from 1 review

Long‐term effects of weight‐reducing drugs in people with hypertension 2021 · Cochrane Headline outcomes only
RR 0.99 [0.7, 1.4]
1 study · 8283 participants
Moderate

Phentermine/topiramate vs placebo

Total mortality · Men and non‐pregnant women ≥ 18 years old with essential hypertension

1 finding from 1 review

Long‐term effects of weight‐reducing drugs in people with hypertension 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1305 participants
Low

Weight‐reducing diets vs no weight‐reducing diets

Total mortality · Men and non‐pregnant women ≥ 18 years old with essential hypertension

1 finding from 1 review

Long‐term effects of weight‐reducing diets in people with hypertension 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 845 participants
Very low

Intervention not reported

Total mortality Systolic targets · Diabetes Mellitus with elevated blood pressure

The intervention showed no clear difference in total mortality Systolic targets (low certainty).

1 finding from 1 review

Blood pressure targets for hypertension in people with diabetes mellitus 2013 · Cochrane Headline outcomes only
RR 1.05 [0.84, 1.3]
1 study · 4734 participants
Low

Intervention not reported

Total mortality Diastolic targets · Diabetes Mellitus with elevated blood pressure

It is very uncertain whether the intervention changes total mortality Diastolic targets (very low certainty).

1 finding from 1 review

Blood pressure targets for hypertension in people with diabetes mellitus 2013 · Cochrane Headline outcomes only
RR 0.73 [0.53, 1.01]
4 studies · 2580 participants
Very low

Lower blood pressure targets vs standard blood pressure targets

Total mortality · adult patients with hypertension

Lower BP target showed no clear difference in total mortality compared with standard BP target (high certainty).

1 finding from 1 review

Blood pressure targets in adults with hypertension 2020 · Cochrane Headline outcomes only
RR 0.95 [0.86, 1.05]
Studies not reported
High