Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 4 · 66.7%Moderate 1 · 16.7%High 1 · 16.7%

Atovaquone‐proguanil vs artesunate‐atovaquone‐proguanil

Total failure: day 28 (PCR‐adjusted) · children and adults

Atovaquone‐proguanil showed no clear difference in total failure day 28 PCR‐adjusted compared with artesunate‐atovaquone‐proguanil (low certainty).

1 finding from 1 review

Atovaquone‐proguanil for treating uncomplicated Plasmodium falciparum malaria 2021 · Cochrane Headline outcomes only
RR 5.143 [0.61, 43.52]
2 studies · 375 participants
Low

Atovaquone‐proguanil vs artesunate‐atovaquone‐proguanil

Total failure: day 42 (PCR‐adjusted) · children and adults

Atovaquone‐proguanil showed no clear difference in total failure [day 42 PCR‐adjusted compared with artesunate‐atovaquone‐proguanil (moderate certainty).

1 finding from 1 review

Atovaquone‐proguanil for treating uncomplicated Plasmodium falciparum malaria 2021 · Cochrane Headline outcomes only
RR 1.84 [0.95, 3.56]
2 studies · 1258 participants
Moderate

Atovaquone‐proguanil vs artemether‐lumefantrine (AL)

Total failure: day 28 (PCR‐adjusted) · children and adults

Atovaquone‐proguanil showed no clear difference in total failure day 28 PCR‐adjusted compared with artemether‐lumefantrine (low certainty).

1 finding from 1 review

Atovaquone‐proguanil for treating uncomplicated Plasmodium falciparum malaria 2021 · Cochrane Headline outcomes only
RR 5 [0.25, 99.95]
1 study · 60 participants
Low

Atovaquone‐proguanil vs artemether‐lumefantrine (AL)

Total failure: day 42 (PCR‐adjusted) · children and adults

Atovaquone‐proguanil showed no clear difference in total failure day 42 PCR‐adjusted compared with artemether‐lumefantrine (low certainty).

1 finding from 1 review

Atovaquone‐proguanil for treating uncomplicated Plasmodium falciparum malaria 2021 · Cochrane Headline outcomes only
RR 3 [0.19, 47.12]
1 study · 208 participants
Low

Atovaquone‐proguanil vs artesunate‐amodiaquine (AS‐AQ)

Total failure: day 28 (PCR‐adjusted) · children under 5 years of age

Atovaquone‐proguanil showed no clear difference in total failure day 28 PCR‐adjusted compared with artesunate‐amodiaquine (low certainty).

1 finding from 1 review

Atovaquone‐proguanil for treating uncomplicated Plasmodium falciparum malaria 2021 · Cochrane Headline outcomes only
RR 3.19 [0.67, 15.22]
1 study · 132 participants
Low

Atovaquone‐proguanil vs mefloquine plus artesunate (MQ + AS)

Total failure: day 42 (PCR‐adjusted) · children and adults

Atovaquone‐proguanil showed no clear difference in total failure day 42 PCR‐adjusted compared with artesunate‐mefloquine (high certainty).

1 finding from 1 review

Atovaquone‐proguanil for treating uncomplicated Plasmodium falciparum malaria 2021 · Cochrane Headline outcomes only
RR 1.15 [0.57, 2.34]
2 studies · 1168 participants
High