Findings

What do systematic reviews say?

2 questions · 3 findings · 2 reviews · Infectious Diseases

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 3 · 100%Moderate 0 · 0%High 0 · 0%

Total failure: day 28 (unadjusted) · adults and children with uncomplicated P falciparum malaria

Pyronaridine‐artesunate (PY‐AS) may leads to lower total failure: day 28 (unadjusted) compared with artemether‐lumefantrine (AL) (low certainty).

2 findings from 1 review

Pyronaridine‐artesunate for treating uncomplicated Plasmodium falciparum malaria 2022 · Cochrane Headline outcomes only
RR 0.27 [0.13, 0.58]
4 studies · 3149 participants
Low
Pyronaridine‐artesunate for treating uncomplicated Plasmodium falciparum malaria 2022 · Cochrane Headline outcomes only
RR 0.61 [0.46, 0.82]
4 studies · 3080 participants
Low

Total failure day 42 PCR‐unadjusted · children and adults

Atovaquone‐proguanil showed no clear difference in total failure day 42 PCR‐unadjusted compared with artemether‐lumefantrine (low certainty).

1 finding from 1 review

Atovaquone‐proguanil for treating uncomplicated Plasmodium falciparum malaria 2021 · Cochrane Headline outcomes only
RR 5 [0.25, 99.95]
1 study · 60 participants
Low