Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews

No studies found 2 · 28.6%GRADE not reported 0 · 0%Very low 1 · 14.3%Low 3 · 42.9%Moderate 0 · 0%High 1 · 14.3%

Amputation · people with critical limb ischaemia

Prostanoids showed no clear difference in total amputations compared with naftidrofuryl (low certainty).

1 finding from 1 review

Prostanoids for critical limb ischaemia 2018 · Cochrane Headline outcomes only
RR 0.96 [0.57, 1.64]
1 study · 29 participants
Low

Amputation · people with critical limb ischaemia

Prostanoids showed no clear difference in total amputations compared with placebo (high certainty).

1 finding from 1 review

Prostanoids for critical limb ischaemia 2018 · Cochrane Headline outcomes only
RR 0.97 [0.86, 1.09]
12 studies · 2825 participants
High

Amputation · people with critical limb ischaemia

It is very uncertain whether prostanoids changes total amputations compared with pentoxifylline (very low certainty).

1 finding from 1 review

Prostanoids for critical limb ischaemia 2018 · Cochrane Headline outcomes only
RR 0.5 [0.05, 5.27]
1 study · 70 participants
Very low

Amputation · people with critical limb ischaemia

PGE1 may leads to lower total amputations compared with ATP (low certainty).

1 finding from 1 review

Prostanoids for critical limb ischaemia 2018 · Cochrane Headline outcomes only
RR 0.26 [0.09, 0.74]
2 studies · 91 participants
Low

Amputation · people with critical limb ischaemia

The review found no eligible studies for this question.

1 finding from 1 review

Prostanoids for critical limb ischaemia 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Amputation · people with critical limb ischaemia

Iloprost showed no clear difference in total amputations compared with PGE1 (low certainty).

1 finding from 1 review

Prostanoids for critical limb ischaemia 2018 · Cochrane Headline outcomes only
RR 0.89 [0.66, 1.21]
1 study · 209 participants
Low

Amputation · people with critical limb ischaemia

The review found no eligible studies for this question.

1 finding from 1 review

Prostanoids for critical limb ischaemia 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found