What do systematic reviews say?

Summary of findings: cycled vs culture‐based antibiotic therapy

Summary of findings: cycled showed no clear difference in adverse events: severe adverse events (total) compared with culture‐based antibiotic therapy (moderate certainty).

• Treatments for preventing recurrence of infection with Pseudomonas aeruginosa in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
  RR 0.65 [0.39, 1.11]
  1 study · 253 participants
  Moderate

Summary of findings ‐ Inhaled mannitol vs control (non‐respirable mannitol)

• Inhaled mannitol for cystic fibrosis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  123 participants
  Low

Summary of findings ‐ Inhaled mannitol vs dornase alfa

• Inhaled mannitol for cystic fibrosis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  231 participants
  Very low

Summary of findings ‐ 400 mg inhaled mannitol vs 50 mg inhaled mannitol

• Inhaled mannitol for cystic fibrosis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 600 participants
  Moderate

Summary of findings ‐ Inhaled mannitol plus dornase alfa vs dornase alfa

• Inhaled mannitol for cystic fibrosis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  231 participants
  Very low