What do systematic reviews say?

Hyperbaric oxygen (following replantation) vs control

It is very uncertain whether hyperbaric oxygen (following replantation) changes tooth survival at 12 months compared with control (very low certainty).

• Interventions for treating traumatised permanent front teeth: avulsed (knocked out) and replanted 2019 · Cochrane All outcomes

  12 months
  RR 1.21 [1.07, 1.36]
  1 study · 69 participants
  Very low

Thymosin alpha 1 (10-minute soak prior to replantation) vs Normal saline

It is very uncertain whether thymosin alpha 1 (10-minute soak prior to replantation) changes tooth survival at 12 months compared with control (saline) (very low certainty).

• Interventions for treating traumatised permanent front teeth: avulsed (knocked out) and replanted 2019 · Cochrane All outcomes

  12 months
  RR 1.46 [1.11, 1.91]
  1 study · 73 participants
  Very low
• Interventions for treating traumatised permanent front teeth: avulsed (knocked out) and replanted 2019 · Cochrane All outcomes

  48 months
  RR 3.58 [1.86, 6.89]
  1 study · 73 participants
  Very low

Ledermix root canal medicament (day 0 to 10) vs Ultracal root canal medicament (day 7 to 10)

• Interventions for treating traumatised permanent front teeth: avulsed (knocked out) and replanted 2019 · Cochrane All outcomes

  12 months
  Tooth survival at 12 months: Not estimable (due to no events in either arm); 27 teeth in 22 patients (1 RCT). At 12 months, no teeth were lost. 1 tooth was lost at 16 months in the Ultracal group.
  1 study · 22 participants
  Very low