Findings

What do systematic reviews say?

4 questions · 4 findings · 2 reviews · Epilepsy

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 4 · 100%Moderate 0 · 0%High 0 · 0%

VGB vs CBZ monotherapy

Time to treatment withdrawal · people with epilepsy

VGB showed no clear difference in time to treatment withdrawal compared with CBZ monotherapy (low certainty).

1 finding from 1 review

Vigabatrin versus carbamazepine monotherapy for epilepsy 2015 · Cochrane Headline outcomes only
HR 0.75 [0.52, 1.1]
1 study · 446 participants
Low

Intervention not reported

Time to treatment withdrawal ‐ all participants Range of · adults and children with newly diagnosed partial onset or generalised onset seizures

The intervention may leads to higher time to treatment withdrawal ‐ all participants Range of (low certainty).

1 finding from 1 review

Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalised onset tonic-clonic seizures 2013 · Cochrane Headline outcomes only
HR 1.62 [1.23, 2.14]
3 studies · 499 participants
Low

Intervention not reported

Time to treatment withdrawal ‐ stratified by seizure type ‐ Partial onset Range of · adults and children with newly diagnosed partial onset or generalised onset seizures

The intervention may leads to higher time to treatment withdrawal ‐ stratified by seizure type ‐ Partial… (low certainty).

1 finding from 1 review

Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalised onset tonic-clonic seizures 2013 · Cochrane Headline outcomes only
HR 1.48 [1.1, 1.98]
3 studies · 404 participants
Low

Intervention not reported

Time to treatment withdrawal ‐ stratified by seizure type ‐ Generalised seizures Range of · adults and children with newly diagnosed partial onset or generalised onset seizures

The intervention may leads to higher time to treatment withdrawal ‐ stratified by seizure type ‐… (low certainty).

1 finding from 1 review

Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalised onset tonic-clonic seizures 2013 · Cochrane Headline outcomes only
HR 4.04 [1.61, 10.14]
2 studies · 95 participants
Low