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Evidence found and GRADE certainty

5 questions · 5 findings · 5 reviews · Epilepsy

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Sodium valproate vs phenytoin monotherapy

Time to treatment failure (any reason related to treatment) All participants Range of · adults and children with newly‐onset focal onset or generalised tonic‐clonic seizures

Sodium valproate showed no clear difference in time to treatment failure (any reason related to treatment) All… compared with phenytoin monotherapy (moderate certainty).

1 finding from 1 review

Carbamazepine vs phenytoin

Time to treatment failure (any reason related to treatment) All participants Range of · adults and children with newly onset partial or generalised epilepsy

Carbamazepine showed no clear difference in time to treatment failure (any reason related to treatment)All… compared with phenytoin (time to treatment failure) (moderate certainty).

1 finding from 1 review

Lamotrigine vs carbamazepine

Time to treatment failure (any reason related to treatment) All participants Range of · adults and children with focal onset or generalised onset seizures (generalised tonic‐clonic with or without other generalised seizure…

Summary of findings: lamotrigine probably leads to lower time to treatment failure (any reason related to treatment) All… compared with carbamazepine (moderate certainty).

1 finding from 1 review

Carbamazepine vs phenobarbitone

Time to treatment failure (any reason related to treatment) All participants Range of · adults and children with newly onset partial or generalised epilepsy

Carbamazepine probably leads to lower time to treatment failure (any reason related to treatment) All… compared with phenobarbitone (moderate certainty).

1 finding from 1 review

Topiramate vs carbamazepine

Time to treatment failure (any reason related to treatment) All participants ‐ adjusted by seizure type Range of · adults and children with newly onset partial or generalised epilepsy

Topiramate showed no clear difference in time to treatment failure (any reason related to treatment) All… compared with carbamazepine (moderate certainty).

1 finding from 1 review