Findings

What do systematic reviews say?

2 questions · 2 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 1 · 50%High 1 · 50%

Carbamazepine vs phenytoin

Time to first seizure (post‐randomisation) Subgroup: focal onset seizures Range of · adults and children with newly onset partial or generalised epilepsy

Carbamazepine showed no clear difference in time to first seizure after randomisation Subgroup: focal onset… compared with phenytoin (secondary outcomes) (moderate certainty).

1 finding from 1 review

Carbamazepine versus phenytoin monotherapy for epilepsy: an individual participant data review 2019 · Cochrane Headline outcomes only
HR 1.13 [0.89, 1.43]
4 studies · 432 participants
Moderate

Topiramate vs carbamazepine

Time to first seizure (post‐randomisation) Subgroup: focal onset seizures Range of · adults and children with newly onset partial or generalised epilepsy

Topiramate showed no clear difference in time to first seizure after randomisation Subgroup: focal onset… compared with carbamazepine (high certainty).

1 finding from 1 review

Topiramate versus carbamazepine monotherapy for epilepsy: an individual participant data review 2019 · Cochrane Headline outcomes only
HR 1.12 [0.95, 1.31]
2 studies · 925 participants
High