Findings

What do systematic reviews say?

3 questions · 3 findings · 3 reviews · Dental caries

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No studies found 0 · 0%GRADE not reported 1 · 33.3%Very low 0 · 0%Low 1 · 33.3%Moderate 1 · 33.3%High 0 · 0%

Dental cavity liner (e.g. calcium hydroxide, glass ionomer, resin-modified glass ionomer, or flowable composite) placed under the restoration vs No cavity liner or a different liner material

Tooth survival · Patients with deep caries lesions in mature or immature permanent (posterior) teeth, with no symptoms or reversible pulpitis

Cavity liners may make little or no difference to tooth survival (99.4% survival across groups; low certainty).

1 finding from 1 review

Efficacy of different cavity liners compared to no cavity lining in managing deep caries in vital permanent teeth - a… 2025 All outcomes
>=12 months · Dental clinical settings (multiple countries)
No significant difference; 99.4% survival in all groups
12 studies · 1184 participants
Low

PET-CT following chemoradiotherapy (neck dissection only if no/incomplete response) vs Planned neck dissection before or after chemoradiotherapy

Disease-free survival · Adults with oral cavity or oropharyngeal cancer with nodal disease (stage N2 or N3)

1 finding from 1 review

Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
Disease-free survival: outcome not reported in a usable way (Mehanna 2017: disease-specific and other-cause mortality did not differ, P=0.80 and 0.41).
1 study
GRADE not reported

Surgery +/- radiotherapy + (adjuvant) chemotherapy vs Surgery +/- radiotherapy alone (observation or adjuvant radiotherapy only)

Overall survival, post-surgery chemotherapy vs surgery alone (no radiotherapy) · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer

Surgery +/- radiotherapy + (adjuvant) chemotherapy showed no clear difference in overall survival, adjuvant chemotherapy vs observation alone… compared with surgery +/- radiotherapy alone (observation or adjuvant radiotherapy… (moderate certainty).

1 finding from 1 review

Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy 2021 · Cochrane All outcomes
HR 0.95 [0.73, 1.22]
5 studies · 353 participants
Moderate