What do systematic reviews say?

Reduction and pharmacotherapy vs reduction alone

Reduction and pharmacotherapy probably leads to higher subgroup: fast‐acting NRT only; smoking cessation (≥ 6 month compared with reduction alone (moderate certainty).

• Smoking reduction interventions for smoking cessation 2019 · Cochrane Headline outcomes only
  RR 2.56 [1.93, 3.39]
  7 studies · 5323 participants
  Moderate