Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 2 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Severe early childhood caries vs Caries-free controls

Relative abundance of S. mutans in saliva · Children under 6 years with severe early childhood caries and caries-free controls

S. mutans median relative abundance was higher in the S-ECC group, without a comparative effect estimate or CI.

1 finding from 1 review

A systematic review of Streptococcus Mutans and Veillonellae species interactions in dental caries progression:… 2025 All outcomes
USA
Median relative abundance (%) caries 0.73 (range 0.02-22.9) vs control 0.15 (0.006-10.4)
1 study · 50 participants
GRADE not reported

Dental caries (ECC/severe ECC) as exposure/grouping vs Caries-free controls

Relative abundance of S. mutans in saliva · Individuals assessed for dental caries, predominantly children with early childhood caries (ECC) or severe ECC (age about 1 to 4 years)

A few small studies report Streptococcus mutans relative abundance in caries versus caries-free children without pooling; the evidence is ungraded and not meta-analyzed.

1 finding from 1 review

A systematic review of Streptococcus Mutans and Veillonellae species interactions in dental caries progression:… 2025 All outcomes
Community and clinical pediatric dental settings (USA, Hong Kong, Indonesia); saliva or dental plaque microbial sampling
Reported in 2 studies without pooling: Agnello 2017 median S. mutans relative abundance 0.73% (0.02-22.9) in caries vs 0.15% (0.006-10.4) in controls; Chalmers 2015 Streptococcus 35.63+/-17.04 (caries) vs 32.11+/-18.91…
1 study · 50 participants
GRADE not reported