Varenicline leads to higher smoking abstinence at longest compared with placebo or no medication (high certainty).
Varenicline leads to higher smoking abstinence at longest compared with bupropion (high certainty).
Varenicline leads to higher smoking abstinence at longest compared with nicotine replacement therapy monotherapy (high certainty).
Varenicline showed no clear difference in smoking abstinence at longest compared with combination nicotine replacement therapy (low certainty).
It is very uncertain whether varenicline changes smoking abstinence at longest compared with e‐cigarettes (very low certainty).
Cytisine showed no clear difference in smoking abstinence at longest compared with varenicline (low certainty).