What do systematic reviews say?

Neoadjuvant chemotherapy prior to interval surgery (NACT) vs surgery followed by chemotherapy (PDS)

Neoadjuvant chemotherapy prior to interval surgery (NACT) probably leads to lower surgically‐related severe adverse effects (grade 3+) ‐ postoperative… compared with surgery followed by chemotherapy (PDS) (moderate certainty).

• Neoadjuvant chemotherapy before surgery versus surgery followed by chemotherapy for initial treatment in advanced… 2021 · Cochrane Headline outcomes only
  RR 0.22 [0.13, 0.38]
  2 studies · 435 participants
  Moderate

Surgery plus whole brain radiotherapy (WBRT) vs stereotactic radiosurgery

It is very uncertain whether surgery plus whole brain radiotherapy (WBRT) changes adverse events (severe) compared with stereotactic radiosurgery (very low certainty).

• Surgery versus stereotactic radiotherapy for people with single or solitary brain metastasis 2018 · Cochrane Headline outcomes only
  RR 0.13 [0, 2.5]
  1 study · 64 participants
  Very low

Edaravone plus corticosteroids vs corticosteroids

• Interventions for the treatment of brain radionecrosis after radiotherapy or radiosurgery 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 137 participants
  Low

Summary of findings: bevacizumab vs placebo

• Interventions for the treatment of brain radionecrosis after radiotherapy or radiosurgery 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 14 participants
  Low