Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

16 questions · 16 findings · 7 reviews · Headline outcomes only

No studies found 4 · 25%GRADE not reported 0 · 0%Very low 6 · 37.5%Low 5 · 31.3%Moderate 1 · 6.3%High 0 · 0%

Increased vs stable doses of inhaled corticosteroids

Serious adverse events 48 weeks · adults and children with chronic asthma

It is very uncertain whether increased changes serious adverse events 48 weeks compared with stable doses of inhaled corticosteroids (very low certainty).

1 finding from 1 review

Increased vs stable doses of inhaled corticosteroids

Non‐serious adverse events 43 weeks · adults and children with chronic asthma

It is very uncertain whether increased changes non‐serious adverse events 43 weeks compared with stable doses of inhaled corticosteroids (very low certainty).

1 finding from 1 review

Summary of findings: pioglitazone monotherapy vs no intervention

Serious adverse events (N) · people at increased risk for developing type 2 diabetes

Summary of findings: pioglitazone monotherapy showed no clear difference in serious adverse events (N) compared with no intervention (low certainty).

1 finding from 1 review