Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

29 questions · 29 findings · 15 reviews · Haematology

No studies found 3 · 10.3%GRADE not reported 0 · 0%Very low 7 · 24.1%Low 15 · 51.7%Moderate 4 · 13.8%High 0 · 0%

Summary of findings table ‐ Convalescent plasma vs placebo or usual care

Serious adverse events ‐ total · individuals with moderate to severe disease

Summary of findings table ‐ Convalescent plasma showed no clear difference in serious adverse events ‐ total compared with placebo or standard care alone (moderate certainty).

1 finding from 1 review

RBD‐specific polyclonal F(ab') 2 fragments of equine antibodies (EpAbs) vs saline placebo

Serious adverse events (by day 28) · individuals with moderate or severe COVID‐19

RBD‐specific polyclonal F(ab') 2 fragments of equine antibodies… showed no clear difference in serious adverse events (by day 28) compared with saline placebo (low certainty).

1 finding from 1 review

Remdesivir and standard care vs placebo or usual care

Serious adverse events at up to day 28 · hospitalised individuals with COVID‐19 (moderate to severe disease)

Remdesivir and standard care showed no clear difference in serious adverse events at up to day 28 compared with standard care (plus/minus placebo) (low certainty).

1 finding from 1 review

Casirivimab/imdevimab vs placebo

Serious adverse events within 6 months · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

It is very uncertain whether casirivimab/imdevimab changes serious adverse events within 6 months compared with placebo (very low certainty).

1 finding from 1 review