Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

12 questions · 12 findings · 5 reviews · Haematology

No studies found 4 · 33.3%GRADE not reported 0 · 0%Very low 4 · 33.3%Low 2 · 16.7%Moderate 2 · 16.7%High 0 · 0%

Summary of findings table ‐ Convalescent plasma vs placebo or usual care

Serious adverse events ‐ total · individuals with moderate to severe disease

Summary of findings table ‐ Convalescent plasma showed no clear difference in serious adverse events ‐ total compared with placebo or standard care alone (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Daratumumab plus standard therapy vs usual care

Serious adverse events at longest · people with newly diagnosed multiple myeloma ineligible for transplant

Summary of findings table ‐ Daratumumab plus standard therapy probably leads to higher serious adverse events (longest available compared with standard therapy (moderate certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events during the trial period · all trials contributing results to the summary of findings table included people with mild disease (WHO scale 1 to 3)§

The intervention showed no clear difference in serious adverse events during the trial period (low certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events during the trial period · people with moderate to severe disease (WHO scale 4–9); all trials contributing results to the summary of findings table investigated…

It is very uncertain whether the intervention changes serious adverse events during the trial period (very low certainty).

1 finding from 1 review