Findings

What do systematic reviews say?

4 questions · 4 findings · 2 reviews · Headline outcomes only

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 25%Moderate 2 · 50%High 1 · 25%

Antibiotics vs placebo

Serious adverse events WMD of · Adults (aged 40 or over) with COPD presenting with 1 or more exacerbations in the previous year. The 2 larger studies (Albert 2011; Sethi…

Antibiotics showed no clear difference in serious adverse events WMD of compared with placebo (moderate certainty).

1 finding from 1 review

Prophylactic antibiotic therapy for chronic obstructive pulmonary disease (COPD) 2018 · Cochrane Headline outcomes only
OR 0.88 [0.74, 1.05]
9 studies · 2978 participants
Moderate

28 days on/off antibiotic regimen vs 28 days on/off placebo regimen

Serious adverse events · people with bronchiectasis

28 days on/off antibiotic regimen showed no clear difference in serious adverse events compared with 28 days on/off placebo regimen (low certainty).

1 finding from 1 review

Intermittent prophylactic antibiotics for bronchiectasis 2022 · Cochrane Headline outcomes only
OR 1 [0.68, 1.46]
Studies not reported
Low

14 days on/off antibiotic regimen vs 28 days on/off antibiotic regimen

Serious adverse events · people with bronchiectasis

14 days on/off antibiotic regimen showed no clear difference in serious adverse events compared with 28 days on/off antibiotic regimen (moderate certainty).

1 finding from 1 review

Intermittent prophylactic antibiotics for bronchiectasis 2022 · Cochrane Headline outcomes only
OR 0.83 [0.37, 1.86]
Studies not reported
Moderate

14 days on/off antibiotic regimen vs 14 days on/off placebo regimen

Serious adverse events · people with bronchiectasis

14 days on/off antibiotic regimen showed no clear difference in serious adverse events compared with 14 days on/off placebo regimen (high certainty).

1 finding from 1 review

Intermittent prophylactic antibiotics for bronchiectasis 2022 · Cochrane Headline outcomes only
OR 0.92 [0.63, 1.33]
Studies not reported
High