What do systematic reviews say?

Hypothermic oxygenated perfusion (HOPE) vs static cold storage (SCS)

Hypothermic oxygenated perfusion (HOPE) showed no clear difference in serious adverse events compared with static cold storage (SCS) (moderate certainty).

• Machine perfusion in liver transplantation 2023 · Cochrane Headline outcomes only
  OR 0.91 [0.42, 1.98]
  2 studies · 156 participants
  Moderate

Hypothermic oxygenated perfusion (HOPE) vs static cold storage (SCS)

• Machine perfusion in liver transplantation 2023 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 312 participants
  GRADE not reported

Antibiotics vs placebo

Antibiotics showed no clear difference in serious adverse events WMD of compared with placebo (moderate certainty).

• Prophylactic antibiotic therapy for chronic obstructive pulmonary disease (COPD) 2018 · Cochrane Headline outcomes only
  OR 0.88 [0.74, 1.05]
  9 studies · 2978 participants
  Moderate

Higher vs lower FiO2 or targets of arterial oxygenation

It is very uncertain whether higher changes proportion of participants with ≥ 1 serious adverse events according… compared with lower FiO2 or targets of arterial oxygenation (very low certainty).

• Higher versus lower fractions of inspired oxygen or targets of arterial oxygenation for adults admitted to the… 2023 · Cochrane Headline outcomes only
  RR 1.01 [0.96, 1.06]
  17 studies · 9466 participants
  Very low