Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

10 questions · 10 findings · 4 reviews · Kidney and Transplant

No studies found 1 · 10%GRADE not reported 0 · 0%Very low 0 · 0%Low 5 · 50%Moderate 4 · 40%High 0 · 0%

Azathioprine vs cyclophosphamide

Serious adverse events · adults with renal vasculitis for maintenance therapy

Azathioprine showed no clear difference in serious adverse events compared with cyclophosphamide (moderate certainty).

1 finding from 1 review

Leflunomide vs methotrexate

Serious adverse events* · adults with renal vasculitis for maintenance therapy

Leflunomide showed no clear difference in serious adverse events* compared with methotrexate (low certainty).

1 finding from 1 review

Cyclosporin vs mycophenolate mofetil with pulse dexamethasone

Adverse effects (weeks 0 to 26): serious infection requiring hospitalisation · idiopathic steroid‐resistant nephrotic syndrome in children

Cyclosporin showed no clear difference in adverse events (weeks 0 to 26): serious infection requiring… compared with mycophenolate mofetil with pulse dexamethasone (low certainty).

1 finding from 1 review

Calcineurin inhibitor vs IV cyclophosphamide

Adverse events: treatment failure (non response, serious infection, persistently elevated creatinine) at 6 months · idiopathic steroid‐resistant nephrotic syndrome in children

Calcineurin inhibitor probably leads to lower adverse events: treatment failure at 6 months (non response, serious… compared with IV cyclophosphamide (moderate certainty).

1 finding from 1 review