Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

24 questions · 24 findings · 8 reviews · Gut

No studies found 7 · 29.2%GRADE not reported 0 · 0%Very low 5 · 20.8%Low 10 · 41.7%Moderate 2 · 8.3%High 0 · 0%

Chemmotherapy combined with biological therapy vs chemotherapy alone

Serious adverse events · advanced gastric and oesophago‐gastric junction adenocarcinoma

It is very uncertain whether chemmotherapy combined with biological therapy changes serious adverse events compared with chemotherapy (very low certainty).

1 finding from 1 review

Chemotherapy vs placebo, best supportive care (BSC) or no treatment

Serious adverse events · advanced gastric and oesophago‐gastric junction adenocarcinoma

Chemotherapy probably leads to higher serious adverse events compared with placebo, best supportive care (BSC) or no treatment (moderate certainty).

1 finding from 1 review

Biological therapy vs placebo, best supportive care (BSC) or no treatment

Serious adverse events · advanced gastric and oesophago‐gastric junction adenocarcinoma

Biological therapy showed no clear difference in serious adverse events compared with placebo, best supportive care (BSC) or no treatment (low certainty).

1 finding from 1 review

Azathioprine or 6‐mercaptopurine vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Serious adverse events · people with surgically‐induced remission in Crohn's disease

It is very uncertain whether azathioprine or 6‐mercaptopurine changes serious adverse events compared with 5‐aminosalicylic acid (very low certainty).

1 finding from 1 review