Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

44 questions · 44 findings · 23 reviews · Headline outcomes only

No studies found 4 · 9.1%GRADE not reported 3 · 6.8%Very low 12 · 27.3%Low 12 · 27.3%Moderate 9 · 20.5%High 4 · 9.1%

Febuxostat 80 mg/day vs placebo

Serious adverse events · people with chronic gout

Febuxostat 80 mg/day showed no clear difference in serious Adverse Events compared with placebo (moderate certainty).

1 finding from 1 review

Febuxostat 80 mg/day vs allopurinol

Serious adverse events · people with chronic gout

Febuxostat 80 mg/day showed no clear difference in serious Adverse Events compared with allopurinol (moderate certainty).

1 finding from 1 review

Febuxostat 40 mg/day vs placebo

Serious adverse events · people with chronic gout

Febuxostat 40 mg/day probably leads to higher serious Adverse Events compared with placebo (moderate certainty).

1 finding from 1 review

Febuxostat 120 mg/day vs placebo

Serious adverse events · patients with chronic cout

Febuxostat 120 mg/day showed no clear difference in serious Adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Pyronaridine‐artesunate (PY‐AS) vs mefloquine plus artesunate (MQ + AS)

Serious adverse events (42 days) · adults and children with uncomplicated P falciparum malaria

Pyronaridine‐artesunate (PY‐AS) showed no clear difference in serious adverse events (42 days) compared with mefloquine plus artesunate (MQ + AS) (low certainty).

1 finding from 1 review