Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

29 questions · 29 findings · 10 reviews

No studies found 8 · 27.6%GRADE not reported 0 · 0%Very low 12 · 41.4%Low 6 · 20.7%Moderate 3 · 10.3%High 0 · 0%

Chemotherapy vs placebo, best supportive care (BSC) or no treatment

Serious adverse events · advanced gastric and oesophago‐gastric junction adenocarcinoma

Chemotherapy probably leads to higher serious adverse events compared with placebo, best supportive care (BSC) or no treatment (moderate certainty).

1 finding from 1 review

Cediranib plus chemotherapy vs placebo plus chemotherapy

Serious adverse events · women with persistent, recurrent, or metastatic cervical cancer

Cediranib plus chemotherapy showed no clear difference in serious adverse events compared with placebo plus chemotherapy (low certainty).

1 finding from 1 review

Cediranib plus chemotherapy vs placebo plus chemotherapy

Specific adverse events: serious haemorrhage · women with persistent, recurrent, or metastatic cervical cancer

It is very uncertain whether cediranib plus chemotherapy changes specific adverse events: serious haemorrhage compared with placebo plus chemotherapy (very low certainty).

1 finding from 1 review

Cediranib plus chemotherapy vs placebo plus chemotherapy

Specific adverse events: serioushypertension · women with persistent, recurrent, or metastatic cervical cancer

It is very uncertain whether cediranib plus chemotherapy changes specific adverse events: serioushypertension compared with placebo plus chemotherapy (very low certainty).

1 finding from 1 review

Bevacizumab plus chemotherapy vs chemotherapy alone

Specific adverse events: serious haemorrhage · women with persistent, recurrent, or metastatic cervical cancer

Bevacizumab plus chemotherapy may leads to higher specific adverse events: serious haemorrhage compared with chemotherapy (low certainty).

1 finding from 1 review

Cediranib plus chemotherapy vs placebo plus chemotherapy

Specific adverse events: serious thromboembolic events · women with persistent, recurrent, or metastatic cervical cancer

It is very uncertain whether cediranib plus chemotherapy changes specific adverse events: serious thromboembolic events compared with placebo plus chemotherapy (very low certainty).

1 finding from 1 review

Bevacizumab plus chemotherapy vs chemotherapy alone

Specific adverse events: serious thromboembolic events · women with persistent, recurrent, or metastatic cervical cancer

Bevacizumab plus chemotherapy probably leads to higher specific adverse events: serious thromboembolic events compared with chemotherapy (moderate certainty).

1 finding from 1 review

Chemmotherapy combined with biological therapy vs chemotherapy alone

Serious adverse events · advanced gastric and oesophago‐gastric junction adenocarcinoma

It is very uncertain whether chemmotherapy combined with biological therapy changes serious adverse events compared with chemotherapy (very low certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events · ≥ 15‐year‐old people with late second stage human African gambiense trypanosomiasis (trypanosomes in blood or nymph node fluid and WBC >…

It is very uncertain whether the intervention changes serious adverse events (very low certainty).

1 finding from 1 review