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Evidence found and GRADE certainty

65 questions · 65 findings · 30 reviews

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No studies found 9 · 13.8%GRADE not reported 5 · 7.7%Very low 8 · 12.3%Low 13 · 20%Moderate 23 · 35.4%High 7 · 10.8%

Fixed‐dose combination aclidinium/formoterol vs formoterol

Adverse events (not including serious adverse events): number of participants · patients with chronic obstructive pulmonary disease

Fixed‐dose combination aclidinium/formoterol leads to lower adverse events (not including serious adverse events): number of… compared with formoterol (high certainty).

1 finding from 1 review

Fixed‐dose combination aclidinium/formoterol vs aclidinium alone

Adverse events (not including serious adverse events): number of participants · patients with chronic obstructive pulmonary disease

Fixed‐dose combination aclidinium/formoterol showed no clear difference in adverse events (not including serious adverse events): number of… compared with aclidinium alone (moderate certainty).

1 finding from 1 review

Intervention not reported

Adverse events－serious events Budesonide/formoterol (BDF) versus budesonide (BD) · patients with COPD

It is very uncertain whether the intervention changes adverse events－serious events Budesonide/formoterol (BDF) versus… (very low certainty).

1 finding from 1 review

Multi‐component intervention vs control

Adverse events: number of people experiencing adverse events (all cause or COPD‐related), serious adverse events, mortality · COPD

Multi‐component intervention showed no clear difference in adverse events: number of people experiencing adverse events (all… compared with control (low certainty).

1 finding from 1 review

Single component intervention vs control

Adverse events: number of people experiencing adverse events (all cause or COPD‐related), serious adverse events, mortality · COPD

It is very uncertain whether single component intervention changes adverse events: number of people experiencing adverse events (all… compared with control (very low certainty).

1 finding from 1 review