Findings

What do systematic reviews say?

5 questions · 5 findings · 1 reviews · Haematology

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 4 · 80%Moderate 1 · 20%High 0 · 0%

Chemotherapy alone vs same chemotherapy plus radiotherapy

Secondary malignant neoplasms · Patients with untreated Hodgkin lymphoma (early and advanced stages)

Chemotherapy alone may leads to lower secondary malignant neoplasms compared with same chemotherapy plus radiotherapy (low certainty).

1 finding from 1 review

Optimisation of chemotherapy and radiotherapy for untreated Hodgkin lymphoma patients with respect to second malignant… 2017 · Cochrane Headline outcomes only
OR 0.43 [0.23, 0.82]
3 studies · 1011 participants
Low

Fewer vs more courses of chemotherapy (with or without radiotherapy

Secondary malignant neoplasms · Patients with untreated Hodgkin lymphoma (early stages)

Fewer showed no clear difference in secondary malignant neoplasms compared with more courses of chemotherapy (with or without radiotherapy (moderate certainty).

1 finding from 1 review

Optimisation of chemotherapy and radiotherapy for untreated Hodgkin lymphoma patients with respect to second malignant… 2017 · Cochrane Headline outcomes only
OR 1.1 [0.74, 1.62]
3 studies · 2403 participants
Moderate

Dose‐intensified chemotherapy vs ABVD‐like chemotherapy (with or without radiotherapy

Secondary malignant neoplasms · Patients with untreated Hodgkin lymphoma (advanced stages)

Dose‐intensified chemotherapy showed no clear difference in secondary malignant neoplasms compared with ABVD‐like chemotherapy (with or without radiotherapy (low certainty).

1 finding from 1 review

Optimisation of chemotherapy and radiotherapy for untreated Hodgkin lymphoma patients with respect to second malignant… 2017 · Cochrane Headline outcomes only
OR 1.37 [0.89, 2.1]
7 studies · 2996 participants
Low

Chemotherapy plus involved‐field radiation vs same chemotherapy plus extended‐field radiation

Secondary malignant neoplasms · Patients with untreated Hodgkin lymphoma (early stages)

Chemotherapy plus involved‐field radiation showed no clear difference in secondary malignant neoplasms compared with same chemotherapy plus extended‐field radiation (low certainty).

1 finding from 1 review

Optimisation of chemotherapy and radiotherapy for untreated Hodgkin lymphoma patients with respect to second malignant… 2017 · Cochrane Headline outcomes only
OR 0.86 [0.64, 1.16]
4 studies · 2397 participants
Low

Chemotherapy plus lower‐dose radiation vs same chemotherapy plus higher‐dose radiation

Secondary malignant neoplasms · Patients with untreated Hodgkin lymphoma (early stages)

Chemotherapy plus lower‐dose radiation showed no clear difference in secondary malignant neoplasms compared with same chemotherapy plus higher‐dose radiation (low certainty).

1 finding from 1 review

Optimisation of chemotherapy and radiotherapy for untreated Hodgkin lymphoma patients with respect to second malignant… 2017 · Cochrane Headline outcomes only
OR 1.03 [0.71, 1.5]
3 studies · 2962 participants
Low