What do systematic reviews say?

Prostanoids vs pentoxifylline

It is very uncertain whether prostanoids changes rest‐pain relief compared with pentoxifylline (very low certainty).

• Prostanoids for critical limb ischaemia 2018 · Cochrane Headline outcomes only
  RR 1.4 [0.72, 2.72]
  1 study · 70 participants
  Very low

Prostanoids vs naftidrofuryl

Prostanoids showed no clear difference in rest‐pain relief compared with naftidrofuryl (low certainty).

• Prostanoids for critical limb ischaemia 2018 · Cochrane Headline outcomes only
  RR 1.07 [0.83, 1.39]
  3 studies · 75 participants
  Low

Prostanoids vs placebo

Prostanoids probably leads to higher rest‐pain relief (dichotomous) compared with placebo (moderate certainty).

• Prostanoids for critical limb ischaemia 2018 · Cochrane Headline outcomes only
  RR 1.3 [1.06, 1.59]
  10 studies · 1179 participants
  Moderate

PGE1 vs ATP

• Prostanoids for critical limb ischaemia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 34 participants
  GRADE not reported

PGE1 vs inositol niacinate

PGE1 showed no clear difference in rest‐pain relief compared with inositol niacinate (low certainty).

• Prostanoids for critical limb ischaemia 2018 · Cochrane Headline outcomes only
  RR 1.45 [0.88, 2.37]
  1 study · 65 participants
  Low

Iloprost vs PGE1

Iloprost showed no clear difference in rest‐pain relief compared with PGE1 (low certainty).

• Prostanoids for critical limb ischaemia 2018 · Cochrane Headline outcomes only
  RR 1.15 [0.9, 1.47]
  1 study · 228 participants
  Low

Clinprost vs lipo‐PGE1

Clinprost showed no clear difference in rest‐pain relief compared with lipo‐PGE1 (low certainty).

• Prostanoids for critical limb ischaemia 2018 · Cochrane Headline outcomes only
  RR 1.05 [0.58, 1.87]
  1 study · 67 participants
  Low