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Evidence found and GRADE certainty

7 questions · 7 findings · 4 reviews · Pregnancy and Childbirth

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 3 · 42.9%Low 1 · 14.3%Moderate 0 · 0%High 3 · 42.9%

Betamethasone vs usual care

Respiratory distress syndrome · women undergoing planned elective caesarean section at 37 weeks' gestation and beyond for singleton pregnancy

Effect of antenatal corticosteroids (betamethasone) showed no clear difference in respiratory distress syndrome (RDS) compared with usual care prior to planned caesarean at term on maternal and… (low certainty).

1 finding from 1 review

Corticosteroids vs placebo or no treatment

Respiratory distress syndrome · infants born of women at risk of preterm birth

Neonatal and child outcomes: corticosteroids leads to lower respiratory distress syndrome№ of participants: 11,183(26 RCTs) compared with placebo or no treatment (high certainty).

1 finding from 1 review

Dexamethasone: oral vs intramuscular – fetal/neonatal outcomes

Respiratory distress syndrome · women at risk of preterm birth

It is very uncertain whether dexamethasone: oral changes respiratory distress syndrome compared with intramuscular – fetal/neonatal outcomes (very low certainty).

1 finding from 1 review

Betamethasone acetate plus phosphate vs betamethasone phosphate – fetal/neonatal outcomes

Respiratory distress syndrome · women at risk of preterm birth

It is very uncertain whether betamethasone acetate plus phosphate changes respiratory distress syndrome compared with betamethasone phosphate – fetal/neonatal outcomes (very low certainty).

1 finding from 1 review

Betamethasone 12‐hourly vs 24‐hourly dosing – fetal/neonatal outcomes

Respiratory distress syndrome · women at risk of preterm birth

It is very uncertain whether betamethasone 12‐hourly changes respiratory distress syndrome compared with 24‐hourly dosing – fetal/neonatal outcomes (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroids vs single course

Respiratory distress syndrome · the fetus/neonate/infant

Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroid leads to lower A5: Respiratory distress syndrome – all fetuses randomised compared with single course (high certainty).

1 finding from 1 review