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What do systematic reviews say?

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Evidence found and GRADE certainty

5 questions · 5 findings · 2 reviews · Dementia and Cognitive Improvement

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No studies found 0 · 0%GRADE not reported 1 · 20%Very low 0 · 0%Low 2 · 40%Moderate 2 · 40%High 0 · 0%

Trazodone vs placebo

Number of participants reporting an adverse event · sleep disturbances in dementia

Trazodone showed no clear difference in reporting ≥ 1 adverse event compared with placebo (low certainty).

1 finding from 1 review

Orexin antagonists vs placebo

Number of participants reporting an adverse event · sleep disturbances in dementia

Orexin antagonists showed no clear difference in reporting ≥ 1 adverse event compared with placebo (moderate certainty).

1 finding from 1 review

Melatonin vs placebo

Number of participants reporting an adverse event · sleep disturbances in dementia

Melatonin showed no clear difference in reporting ≥ 1 adverse event compared with placebo (low certainty).

1 finding from 1 review

Vitamin E (capsules 2000 IU/day in two divided doses) vs placebo

Number of participants experiencing any serious adverse events · people with Alzheimer's disease

Vitamin E (capsules 2000 IU/day in two divided doses) showed no clear difference in adverse events Number of participants reporting ≥ 1 serious adverse… compared with placebo (moderate certainty).

1 finding from 1 review