Findings

What do systematic reviews say?

2 questions · 2 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 100%Moderate 0 · 0%High 0 · 0%

IV cyclophosphamide vs IV dexamethasone and oral cyclophosphamide

Treatment response at 18 months ‐ Sustained remission/steroid sensitive relapses Clinical assessment · idiopathic steroid‐resistant nephrotic syndrome in children

IV cyclophosphamide showed no clear difference in treatment response at 18 months: sustained… compared with oral cyclophosphamide plus IV dexamethasone (low certainty).

1 finding from 1 review

Interventions for idiopathic steroid‐resistant nephrotic syndrome in children 2019 · Cochrane Headline outcomes only
RR 1.13 [0.65, 1.96]
1 study · 49 participants
Low

Intravenous vs oral cyclophosphamide

Clinical relapse · SSNS in children

Intravenous may leads to lower relapse at 6 months compared with oral cyclophosphamide (low certainty).

1 finding from 1 review

Non‐corticosteroid immunosuppressive medications for steroid‐sensitive nephrotic syndrome in children 2020 · Cochrane Headline outcomes only
RR 0.54 [0.34, 0.88]
2 studies · 83 participants
Low