Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

28 questions · 28 findings · 12 reviews · Oral medicine and oral cancer

No studies found 15 · 53.6%GRADE not reported 7 · 25%Very low 6 · 21.4%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Amifostine vs no treatment/placebo

Quality of life · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region

Amifostine showed no clear difference in quality of life compared with no treatment/placebo; GRADE not reported.

1 finding from 1 review

Bee propolis (one 500 mg capsule per day) vs placebo

Quality of life · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review

Any antifungal intervention for the treatment of oral candidiasis vs Placebo, no treatment, or another active antifungal intervention

Patient quality of life · Patients with cancer receiving chemotherapy and/or radiotherapy with overt oral candidiasis

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic aciclovir (oral or intravenous) vs placebo

Patient quality of life · Patients being treated for cancer (predominantly haematological malignancies)

The review found no eligible studies for this question.

1 finding from 1 review

Aciclovir (oral or intravenous) for treatment vs placebo

Patient quality of life · Patients being treated for cancer with established oral HSV infection (bone marrow transplant recipients / immunocompromised)

The review found no eligible studies for this question.

1 finding from 1 review

Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole, itraconazole) vs placebo or no treatment

Patient quality of life · Patients with cancer receiving chemotherapy and/or radiotherapy

The review found no eligible studies for this question.

1 finding from 1 review

Zinc vs placebo

Health‐related quality of life · Patients with taste disturbances (dysgeusia/hypogeusia; idiopathic, zinc-deficient, or secondary to chronic renal failure)
1 finding from 1 review
  • Interventions for managing taste disturbances 2017 · Cochrane All outcomes
    Results (health-related quality of life): None of the studies reported data on health-related quality of life. Heckmann 2005 (zinc) reported that signs of depression were less severe (Beck Depression Inventory P<0.05;…
    1 study
    GRADE not reported

Gabapentin vs placebo

QoL · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

The review found no eligible studies for this question.

1 finding from 1 review

Bethanechol vs placebo

QoL · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

The review found no eligible studies for this question.

1 finding from 1 review

Low‐level laser therapy vs placebo

QoL · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

It is very uncertain whether electromagnetic radiation (low-level laser therapy) changes change in quality of life (QoL) compared with placebo (very low certainty).

1 finding from 1 review