What do systematic reviews say?

Low‐level laser therapy vs Placebo (sham) laser therapy

The review found no eligible studies for this question.

• Interventions for iatrogenic inferior alveolar and lingual nerve injury 2014 · Cochrane All outcomes
  Results: 'No studies reported on quality of life ...'. Not reported by the included laser trials.
  0 studies
  No studies found

Any intervention to manage relapse: fixed options (labial braces, lingual braces, fixed lingual wire) or removable options (Hawley's retainer with spring elastomeric module, Bloore removable aligner, other Hawley's retainer modifications, Invisalign, Clearstep) vs no intervention or another intervention

The review found no eligible studies for this question.

• Interventions for managing relapse of the lower front teeth after orthodontic treatment 2013 · Cochrane All outcomes
  No RCTs met the inclusion criteria for this review. After deduplication, the electronic searching identified 527 publications; after reviewing the titles and abstracts, none focused on interventions to correct the…
  0 studies
  No studies found

Low‐level laser therapy vs placebo

It is very uncertain whether electromagnetic radiation (low-level laser therapy) changes change in quality of life (QoL) compared with placebo (very low certainty).

• Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes

  short-term (up to 3 months)
  MD -5.24 [-7.38, -3.09]
  1 study · 58 participants
  Very low

Low income vs High family income

Children from low-income families had higher odds of poor OHRQoL (OR 1.16, 95% CI 1.11-1.21; 4 studies; ungraded).

• The Association of Oral Health Status, demographic characteristics and socioeconomic determinants with Oral… 2020 All outcomes

  Upper-middle-income country (Brazil); studies 2010-2014
  OR 1.16 [1.11, 1.21]
  4 studies
  GRADE not reported

Low maternal education (<=6 years of schooling) vs Higher maternal education (>6 years)

Lower maternal education was associated with poor OHRQoL (OR 1.12, 95% CI 1.00-1.23; 4 studies; high heterogeneity; CI lower bound at the null; ungraded).

• The Association of Oral Health Status, demographic characteristics and socioeconomic determinants with Oral… 2020 All outcomes

  Upper-middle-income countries; studies 2010-2014
  OR 1.12 [1.00, 1.23]
  4 studies
  GRADE not reported

Dental cavity liner (e.g. calcium hydroxide, glass ionomer, resin-modified glass ionomer, or flowable composite) placed under the restoration vs No cavity liner or a different liner material

No included study reported oral health-related quality of life (a planned outcome), so no evidence is available.

• Efficacy of different cavity liners compared to no cavity lining in managing deep caries in vital permanent teeth - a… 2025 All outcomes

  >=6 months · Dental clinical settings (multiple countries)
  no estimate extracted
  0 studies
  No studies found

Alginate (two stage-two step final/wash impression) vs Silicone elastomer (two stage-two step)

Alginate (two stage-two step final/wash impression) may leads to higher participant-reported oral health-related quality of life… compared with silicone elastomer (two stage-two step) (low certainty).

• Final‐impression techniques and materials for making complete and removable partial dentures 2018 · Cochrane All outcomes

  2 weeks
  MD 7.20 [2.71, 11.69]
  1 study · 144 participants
  Low

Amifostine vs no treatment/placebo

Amifostine showed no clear difference in quality of life compared with no treatment/placebo; GRADE not reported.

• Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes

  End of RT; up to 3 months postRT
  MD 0.52 [-0.02, 1.06]
  1 study · 233 participants
  GRADE not reported

Antiseptic mouthrinse vs placebo

The review found no eligible studies for this question.

• Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes
  No quality of life data were reported.
  0 studies
  No studies found

Bethanechol vs placebo

The review found no eligible studies for this question.

• Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes
  No data on either quality of life or other oral related symptoms were reported.
  0 studies
  No studies found

Chinese medicine vs no treatment/placebo

• Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes

  End of intervention to 3 months postRT
  Insufficient evidence to determine any effect on quality of life (Lin 2014; Analysis 6.5)
  1 study
  GRADE not reported

Amifostine (intravenous) vs Amifostine (subcutaneous)

The review found no eligible studies for this question.

• Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes
  No data on either quality of life or other oral related symptoms were reported.
  0 studies
  No studies found

Venalot Depot (coumarin plus troxerutin) vs placebo

The review found no eligible studies for this question.

• Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes
  No data on either quality of life or other oral related symptoms were reported.
  0 studies
  No studies found

Amifostine 200 mg/m2 three times weekly vs Amifostine 200 mg/m2 five times weekly

• Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes

  End of RT and 6, 12, 18, 24 months postRT
  No significant differences between the three treatment arms (Jellema 2006)
  1 study
  GRADE not reported

Bethanechol vs Artificial saliva

The review found no eligible studies for this question.

• Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes
  No data on either quality of life or other oral related symptoms were reported.
  0 studies
  No studies found

Clinical examination with 24-month recall vs Clinical examination with 12-month recall

The review found no eligible studies for this question.

• Recall intervals for oral health in primary care patients 2020 · Cochrane All outcomes

  2 years
  Summary of findings 1 lists 'Oral-health-related quality of life: Not reported' for the 24-month versus 12-month comparison (Wang 1992 did not measure it).
  0 studies
  No studies found

Dental caries vs Absence/lower severity of dental caries

Dental caries is associated with worse OHRQoL in adolescents, with greater severity linked to greater impact (narrative synthesis; no pooled estimate or GRADE rating).

• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes

  Community/school/clinic settings; adolescents 10-19 years; included reviews conducted in multiple countries
  The impact of dental caries on OHRQoL was addressed in five systematic reviews [9, 26, 34, 36, 37]. Three articles report that the greater the severity of the carious lesion, the worse the impact on OHRQoL in…
  5 studies
  GRADE not reported

Higher family income / socioeconomic status vs Lower income / worse socioeconomic status

Higher family income / better socioeconomic status is associated with better OHRQoL in adolescents (narrative synthesis; no pooled estimate or GRADE rating).

• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes

  Community/school/clinic settings; adolescents 10-19 years; included reviews conducted in multiple countries
  Adolescents from families with higher incomes and higher levels of maternal education have better OHRQoL scores [34]. Worse oral health status, older age, female sex and worse socioeconomic status were significantly…
  Studies not reported
  GRADE not reported

Higher parental / maternal education vs Lower parental education (reference)

Higher parental education is associated with better OHRQoL in adolescents (narrative synthesis; no pooled estimate or GRADE rating).

• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes

  Community/school/clinic settings; adolescents 10-19 years; included reviews conducted in multiple countries
  Adolescents from families with higher incomes and higher levels of maternal education have better OHRQoL scores [34]. Children from families with high income, parental education and family economy had better OHRQoL [42].
  Studies not reported
  GRADE not reported

Malocclusion vs Absence/lower severity of malocclusion

Malocclusion is associated with worse oral health-related quality of life in adolescents (narrative synthesis; no pooled estimate or GRADE rating).

• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes

  Community/school/clinic settings; adolescents 10-19 years; included reviews conducted in multiple countries
  The studies who avaliate occlusal disorders, concluded that this pathology have a negative impact on OHRQoL in adolescents.
  Studies not reported
  GRADE not reported