What do systematic reviews say?

Summary of findings table ‐ Oral small molecule inhibitors (apremilast or baricitinib) vs placebo

The review found no eligible studies for this question.

• Treatments for alopecia areata: a network meta‐analysis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Prophylactic aciclovir (oral or intravenous) vs placebo

The review found no eligible studies for this question.

• Interventions for the prevention and treatment of herpes simplex virus in patients being treated for cancer 2009 · Cochrane All outcomes
  None of the prophylactic aciclovir versus placebo trials reported on patient quality of life. For prevention or treatment, no trials reported on duration of hospital stay, amount of analgesia or patient quality of life.
  0 studies
  No studies found

Gentamicin‐impregnated collagen sponge vs no dressing

The review found no eligible studies for this question.

• Dressings and topical agents for the management of open wounds after surgical treatment for sacrococcygeal pilonidal… 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Theory-based oral health education/promotion interventions (HBM, TPB, SCT, HAPA, TTM, PMT, SOC, PRECEDE-PROCEED, MI) vs Control (waitlist, routine/standard oral health education, or minimal intervention)

Theory-based interventions significantly improved oral health-related quality of life (SMD 7.38; low certainty), with very high heterogeneity.

• Health promotion theory-based educational interventions for improving oral health in children and adolescents: a… 2025 All outcomes

  Post-intervention (follow-up 0.5 to 12 months, varies by study) · School-based and community settings; multiple countries (predominantly Iran; also Pakistan, Hong Kong, Lithuania, Thailand) · Overall
  SMD 7.38 [5.57, 9.19]
  4 studies · 4751 participants
  Low

Summary of findings table ‐ Intralesional classical immunosuppresants (betamethasone or triamcinolone) vs placebo

The review found no eligible studies for this question.

• Treatments for alopecia areata: a network meta‐analysis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Negative pressure wound therapy vs conventional open wound healing

The review found no eligible studies for this question.

• Dressings and topical agents for the management of open wounds after surgical treatment for sacrococcygeal pilonidal… 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Psychotherapy preceded by motivational interviewing vs psychotherapy alone

• Psychosocial interventions for conversion and dissociative disorders in adults 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 47 participants
  Very low

Prefabricated foot orthoses vs shoes

• Foot orthoses for treating paediatric flat feet 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Low
• Foot orthoses for treating paediatric flat feet 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Low

Tricyclic antidepressants vs placebo

The review found no eligible studies for this question.

• Pharmacological interventions for somatoform disorders in adults 2014 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Angiotensin receptor neprilysin inhibitors (ARNIs) vs usual care

• Beta‐blockers and inhibitors of the renin‐angiotensin aldosterone system for chronic heart failure with preserved… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  118 participants
  High

Selective serotonin reuptake inhibitors vs placebo

• Pharmacological interventions for the treatment of depression in chronic obstructive pulmonary disease 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 148 participants
  Very low

Acupuncture vs medication

The review found no eligible studies for this question.

• Acupuncture for depression 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Acupuncture vs psychological therapy

The review found no eligible studies for this question.

• Acupuncture for depression 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Acupuncture vs no treatment/wait list/treatment

The review found no eligible studies for this question.

• Acupuncture for depression 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Psychological therapy vs any comparator

• Psychological therapies for anxiety and depression in children and adolescents with long‐term physical conditions 2018 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 464 participants
  Low

New‐generation antidepressants vs placebo

• Pharmacological interventions for somatoform disorders in adults 2014 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 163 participants
  Very low

Manual therapy, prescribed exercises or both vs no intervention or minimal intervention

• Manual therapy and exercise for lateral elbow pain 2024 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 113 participants
  Low

Prevention of UI after radical: PFMT ± biofeedback vs no treatment

• Conservative management for postprostatectomy urinary incontinence 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 105 participants
  Very low

Acupuncture vs medication

The review found no eligible studies for this question.

• Acupuncture for depression 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Acupuncture vs psychological therapy

The review found no eligible studies for this question.

• Acupuncture for depression 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found