What do systematic reviews say?

Higher vs lower FiO2 or targets of arterial oxygenation

• Higher versus lower fractions of inspired oxygen or targets of arterial oxygenation for adults admitted to the… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 1649 participants
  Very low

Serenoa repens vs placebo or no intervention

Serenoa repens showed no clear difference in quality of lifeMeasured by IPSS‐QoL score (range 0 to 6) compared with placebo or no intervention (high certainty).

• Serenoa repens for the treatment of lower urinary tract symptoms due to benign prostatic enlargement 2023 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 1001 participants
  High

Serenoa repens in combination with other phytotherapy vs placebo or no intervention

• Serenoa repens for the treatment of lower urinary tract symptoms due to benign prostatic enlargement 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 265 participants
  Very low

PAE vs TURP

• Prostatic arterial embolization for the treatment of lower urinary tract symptoms in men with benign prostatic… 2022 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 176 participants
  Low

PUL vs sham

• Prostatic urethral lift for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 206 participants
  Moderate

PUL vs TURP

• Prostatic urethral lift for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 72 participants
  Low
• Prostatic urethral lift for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 69 participants
  Low

Aquablation vs transurethral resection of the prostate

• Aquablation of the prostate for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 174 participants
  Low

Naftopidil vs propiverine (anticholinergic)

• Naftopidil for the treatment of lower urinary tract symptoms compatible with benign prostatic hyperplasia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 37 participants
  Low

Naftopidil vs Eviprostat (phytotherapy)

• Naftopidil for the treatment of lower urinary tract symptoms compatible with benign prostatic hyperplasia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 49 participants
  Moderate

Naftopidil vs tamsulosin

• Naftopidil for the treatment of lower urinary tract symptoms compatible with benign prostatic hyperplasia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  11 studies · 878 participants
  Low

Naftopidil vs silodosin (alpha‐blocker)

• Naftopidil for the treatment of lower urinary tract symptoms compatible with benign prostatic hyperplasia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 652 participants
  Low

Intervention not reported

The review found no eligible studies for this question.

• Invasive urodynamic studies for the management of lower urinary tract symptoms (LUTS) in men with voiding dysfunction 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Dental caries vs Absence/lower severity of dental caries

Dental caries is associated with worse OHRQoL in adolescents, with greater severity linked to greater impact (narrative synthesis; no pooled estimate or GRADE rating).

• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes

  Community/school/clinic settings; adolescents 10-19 years; included reviews conducted in multiple countries
  The impact of dental caries on OHRQoL was addressed in five systematic reviews [9, 26, 34, 36, 37]. Three articles report that the greater the severity of the carious lesion, the worse the impact on OHRQoL in…
  5 studies
  GRADE not reported

Higher family income / socioeconomic status vs Lower income / worse socioeconomic status

Higher family income / better socioeconomic status is associated with better OHRQoL in adolescents (narrative synthesis; no pooled estimate or GRADE rating).

• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes

  Community/school/clinic settings; adolescents 10-19 years; included reviews conducted in multiple countries
  Adolescents from families with higher incomes and higher levels of maternal education have better OHRQoL scores [34]. Worse oral health status, older age, female sex and worse socioeconomic status were significantly…
  Studies not reported
  GRADE not reported

Higher parental / maternal education vs Lower parental education (reference)

Higher parental education is associated with better OHRQoL in adolescents (narrative synthesis; no pooled estimate or GRADE rating).

• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes

  Community/school/clinic settings; adolescents 10-19 years; included reviews conducted in multiple countries
  Adolescents from families with higher incomes and higher levels of maternal education have better OHRQoL scores [34]. Children from families with high income, parental education and family economy had better OHRQoL [42].
  Studies not reported
  GRADE not reported

Malocclusion vs Absence/lower severity of malocclusion

Malocclusion is associated with worse oral health-related quality of life in adolescents (narrative synthesis; no pooled estimate or GRADE rating).

• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes

  Community/school/clinic settings; adolescents 10-19 years; included reviews conducted in multiple countries
  The studies who avaliate occlusal disorders, concluded that this pathology have a negative impact on OHRQoL in adolescents.
  Studies not reported
  GRADE not reported

Calf, quadriceps, and hamstring stretching vs no stretching

The review found no eligible studies for this question.

• Non‐drug therapies for the secondary prevention of lower limb muscle cramps 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Insulin monotherapy compared with the addition of oral glucose‐lowering agents to insulin for people with type 2… 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Insulin monotherapy compared with the addition of oral glucose‐lowering agents to insulin for people with type 2… 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Insulin monotherapy compared with the addition of oral glucose‐lowering agents to insulin for people with type 2… 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found