What do systematic reviews say?

Berotralstat vs placebo or active control

• Interventions for the long‐term prevention of hereditary angioedema attacks 2022 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 130 participants
  Moderate

Plasma‐derived C1 esterase inhibitor vs placebo or active control

• Interventions for the long‐term prevention of hereditary angioedema attacks 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 31 participants
  Low

Avoralstat vs placebo

• Interventions for the long‐term prevention of hereditary angioedema attacks 2022 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 93 participants
  Moderate

Acupuncture vs sham

• Acupuncture for neuropathic pain in adults 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 45 participants
  Very low

Oral steroids vs placebo

• Topical and oral steroids for otitis media with effusion (OME) in children 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Moderate

Electromagnetic field treatment vs placebo

• Electromagnetic fields for treating osteoarthritis 2013 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 145 participants
  Moderate

Intranasal steroid spray vs placebo

• Topical and oral steroids for otitis media with effusion (OME) in children 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Low

Acupuncture combined with other active therapy vs other active therapy

• Acupuncture for neuropathic pain in adults 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 104 participants
  Low

DCS and cognitive and behavioural therapies vs placebo and cognitive and behavioural therapies

It is very uncertain whether DCS and cognitive and behavioural therapies changes quality of life Assessed by LIS (scale from: 0 to 48, better… compared with placebo and cognitive and behavioural therapies (very low certainty).

• Augmentation of cognitive and behavioural therapies (CBT) with d‐cycloserine for anxiety and related disorders 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 56 participants
  Very low

Anti‐IL‐4Rα mAb (dupilumab) vs placebo (on top of topical steroids)

• Biologics for chronic rhinosinusitis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 784 participants
  High

Anti‐IgE mAb (omalizumab) vs placebo (on top of topical steroids)

• Biologics for chronic rhinosinusitis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 265 participants
  Moderate

Anti‐IL‐5 mAb (mepolizumab) vs placebo (on top of topical steroids)

• Biologics for chronic rhinosinusitis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 105 participants
  Low

Benralizumab 100 mg vs placebo

• Anti‐IL‐5 therapies for chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 1433 participants
  High

Alginate (two stage-two step final/wash impression) vs Silicone elastomer (two stage-two step)

Alginate (two stage-two step final/wash impression) may leads to higher participant-reported oral health-related quality of life… compared with silicone elastomer (two stage-two step) (low certainty).

• Final‐impression techniques and materials for making complete and removable partial dentures 2018 · Cochrane All outcomes

  2 weeks
  MD 7.20 [2.71, 11.69]
  1 study · 144 participants
  Low

Long‐acting beta2‐agonists vs placebo

Long‐acting beta2‐agonists showed no clear difference in quality of life1 St George's Respiratory Questionnaire (SGRQ); lower… compared with placebo (moderate certainty).

• Long‐acting beta₂‐agonists for chronic obstructive pulmonary disease 2013 · Cochrane Headline outcomes only
  no estimate extracted
  17 studies · 11397 participants
  Moderate

Intervention not reported

• Home care by outreach nursing for chronic obstructive pulmonary disease 2012 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 587 participants
  Low

Intervention not reported

It is very uncertain whether the intervention changes subjective Health Status score (Assessment of Quality of Life Score… (very low certainty).

• Very early versus delayed mobilisation after stroke 2018 · Cochrane Headline outcomes only
  MD 0.07
  1 study · 68 participants
  Very low

Autoinflation vs no treatment

• Autoinflation for otitis media with effusion (OME) in children 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Low

Mepolizumab 100 mg vs placebo

• Anti‐IL‐5 therapies for chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 1285 participants
  Moderate

Dietary interventions vs usual care

• Lifestyle changes for treating psoriasis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 36 participants
  Moderate