Summary of findings 1: Efficacy and safety of IVT lampalizumab 4‐weekly (monthly) vs sham
QoL · adults with GA due to AMD
1 finding from 1 review
- no estimate extracted2 studies · 983 participantsHigh
Findings
What do systematic reviews say?
296 questions · 303 findings · 97 reviews
No studies found 156 · 51.5%GRADE not reported 9 · 3%Very low 54 · 17.8%Low 48 · 15.8%Moderate 32 · 10.6%High 4 · 1.3%
Summary of findings table ‐ Therapeutic exercise plus non‐surgical intervention vs non‐surgical treatment
Quality of life (SRS‐22 Total score) · adolescents with idiopathic scoliosis
1 finding from 1 review
- Therapeutic exercises for idiopathic scoliosis in adolescents 2024 · Cochrane Headline outcomes onlyno estimate extracted1 study · 34 participantsLow
Summary of findings 3: Efficacy and safety of IVT pegcetacoplan 4‐weekly (monthly) vs sham
QoL · adults with GA due to AMD
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Summary of findings: colistimethate dry powder for inhalation (Colobreathe®) vs tobramycin
QoL · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen
1 finding from 1 review
- Inhaled anti‐pseudomonal antibiotics for long‐term therapy in cystic fibrosis 2022 · Cochrane Headline outcomes onlyno estimate extracted1 study · 374 participantsLow
Summary of findings ‐ triple therapy: VX‐659‐tezacaftor‐ivacaftor/deutivacaftor vs control
Quality of life: CFQ‐R respiratory domain: absolute change from baseline · adults with cystic fibrosis and either F508del/MF or F508del/F508del genotype
1 finding from 1 review
- Corrector therapies (with or without potentiators) for people with cystic fibrosis with class II CFTR gene variants… 2023 · Cochrane Headline outcomes onlyno estimate extracted1 study · 382 participantsModerate
Summary of findings for the main comparison: comprehensive care programmes vs usual care
Child health, functioning, and quality of life Pediatric Quality of Life Inventory (PedsQL) · children with medical complexity
1 finding from 1 review
- Comprehensive care programmes for children with medical complexity 2024 · Cochrane Headline outcomes onlyno estimate extracted3 studies · 701 participantsLow
Summary of findings ‐ dual therapy: lumacaftor plus ivacaftor (once daily) vs placebo
Quality of life ‐ (EuroQol) EQ‐5D‐3L Index Score (total score): absolute change from baseline · adults and children with cystic fibrosis
1 finding from 1 review
- Corrector therapies (with or without potentiators) for people with cystic fibrosis with class II CFTR gene variants… 2023 · Cochrane Headline outcomes onlyno estimate extracted2 studies · 1061 participantsModerate
Summary of findings ‐ triple therapy: elexacaftor‐tezacaftor‐ivacaftor/deutivacaftor vs control
Quality of life: CFQ‐R respiratory domain: absolute change from baseline · adults with cystic fibrosis and either F508del/MF or F508del/F508del genotype
1 finding from 1 review
- Corrector therapies (with or without potentiators) for people with cystic fibrosis with class II CFTR gene variants… 2023 · Cochrane Headline outcomes onlyno estimate extracted3 studies · 599 participantsModerate
Summary of findings ‐ nebulisers for delivering dornase alfa conventional system vs VMT
Quality of life CFQ‐R scores (treatment burden domain and respiratory domain) · adults and children with cystic fibrosis
1 finding from 1 review
- no estimate extracted1 study · 85 participantsVery low
Summary of findings 4: Efficacy and safety of IVT pegcetacoplan 8‐weekly (every other month) vs sham
QoL · adults with GA due to AMD
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Summary of findings 2: Efficacy and safety of IVT lampalizumab 6‐ to 8‐weekly (every other month) vs sham
QoL · adults with GA due to AMD
1 finding from 1 review
- no estimate extracted2 studies · 1003 participantsModerate
Metformin vs insulin
Quality of life Short‐Form 36 health survey (SF‐36)
1 finding from 1 review
- Metformin monotherapy for adults with type 2 diabetes mellitus 2020 · Cochrane Headline outcomes onlyno estimate extracted1 study · 91 participantsVery low
Summary of findings table ‐ Platinum‐sensitive recurrent EOC: PARPi monotherapy vs placebo (maintenance therapy)
QoL · platinum‐sensitive recurrent EOC
1 finding from 1 review
- Poly(ADP‐ribose) polymerase (PARP) inhibitors for the treatment of ovarian cancer 2022 · Cochrane Headline outcomes onlyno estimate extracted1 study · 339 participantsModerate
Summary of findings: catgut implantation at acupoints plus antiepileptic drugs vs antiepileptic drugs alone
Post‐treatment quality of life (QOLIE‐31 score, which has a range of 0‐200, with higher score indicates better quality of life) ( · people with epilepsy
1 finding from 1 review
- no estimate extracted1 study · 120 participantsLow
Summary of findings for the main comparison: comprehensive care programmes vs usual care
Parent health, functioning, and quality of life Patient‐Reported Outcomes Measurement Information System (PROMIS) (higher scores = more of the outcome of interest, which can mean improvement or deterioration depending on the outcome) · children with medical complexity
1 finding from 1 review
- Comprehensive care programmes for children with medical complexity 2024 · Cochrane Headline outcomes onlyno estimate extracted1 study · 207 participantsModerate
Summary of findings: continuous cycles alternating aztreonam lysine for inhalation with tobramycin for inhalation solution vs continuous cycles alternating placebo with tobramycin
Quality of life: respiratory domain · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen
1 finding from 1 review
- Inhaled anti‐pseudomonal antibiotics for long‐term therapy in cystic fibrosis 2022 · Cochrane Headline outcomes onlyno estimate extracted1 study · 90 participantsLow