Findings

What do systematic reviews say?

4 questions · 4 findings · 3 reviews · Oral and maxillofacial surgery

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No studies found 1 · 25%GRADE not reported 2 · 50%Very low 1 · 25%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Any experimental intervention (surgical or non-surgical) vs None (placebo or no treatment)

Quality of life · People of any age and either sex, in any setting, with BRONJ; bisphosphonate exposure past or current; includes people with cancer and…

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for treating bisphosphonate‐related osteonecrosis of the jaw (BRONJ) 2016 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Combined HBO and perioperative antibiotics prior to dental implant therapy vs antibiotics alone

Adverse effects (including quality of life) · Adults with head and neck cancer undergoing curative or adjuvant radiotherapy (at risk of osteoradionecrosis of the jaws)

1 finding from 1 review

Interventions for preventing osteoradionecrosis of the jaws in adults receiving head and neck radiotherapy 2019 · Cochrane All outcomes
1 year
This comparison was only made in 1 study which reported no serious adverse events associated with HBO therapy. Quality of life measures (oral status, functioning, satisfaction) showed emotional functioning and pain…
1 study · 26 participants
Very low

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

Quality of life · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)

1 finding from 1 review

Interventions for treating bisphosphonate‐related osteonecrosis of the jaw (BRONJ) 2016 · Cochrane All outcomes
Baseline and 6 months
no estimate extracted
1 study · 49 participants
GRADE not reported

Hyperbaric oxygen therapy (HBO) as an adjunct to conventional therapy vs conventional therapy

Quality of life · People with established (manifest) MRONJ

1 finding from 1 review

Interventions for managing medication‐related osteonecrosis of the jaw 2022 · Cochrane All outcomes
6 months
QoL measured with the Duke Health Profile; only within-group comparisons were provided; no score values, so a between-group analysis was not possible.
1 study
GRADE not reported