What do systematic reviews say?

Combination therapy vs placebo

• Anticholinergics combined with alpha‐blockers for treating lower urinary tract symptoms related to benign prostatic… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 991 participants
  Very low

Silodosin vs placebo

• Silodosin for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia 2017 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 820 participants
  Moderate

Serenoa repens vs placebo or no intervention

Serenoa repens showed no clear difference in quality of lifeMeasured by IPSS‐QoL score (range 0 to 6) compared with placebo or no intervention (high certainty).

• Serenoa repens for the treatment of lower urinary tract symptoms due to benign prostatic enlargement 2023 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 1001 participants
  High

Serenoa repens in combination with other phytotherapy vs placebo or no intervention

• Serenoa repens for the treatment of lower urinary tract symptoms due to benign prostatic enlargement 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 265 participants
  Very low