Findings

What do systematic reviews say?

2 questions · 4 findings · 1 reviews · Gut

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 25%Low 1 · 25%Moderate 2 · 50%High 0 · 0%

Methotrexate vs placebo

Maintenance of clinical remission · Participants with Crohn's disease in remission

Methotrexate probably leads to higher proportion of patients maintaining clinical remission compared with placebo (moderate certainty).

3 findings from 1 review

Methotrexate for maintenance of remission in Crohn's disease 2014 · Cochrane Headline outcomes only
RR 1.57 [1.1, 2.23]
2 studies · 98 participants
Moderate
Methotrexate for maintenance of remission in Crohn's disease 2014 · Cochrane Headline outcomes only
RR 1.67 [1.05, 2.67]
1 study · 76 participants
Moderate
Methotrexate for maintenance of remission in Crohn's disease 2014 · Cochrane Headline outcomes only
RR 1.35 [0.86, 2.12]
1 study · 22 participants
Low

Methotrexate vs 6‐mercaptopurine

Maintenance of clinical remission · Participants with Crohn's disease in remission

It is very uncertain whether methotrexate changes proportion of patients maintaining clinical remission compared with 6‐mercaptopurine (very low certainty).

1 finding from 1 review

Methotrexate for maintenance of remission in Crohn's disease 2014 · Cochrane Headline outcomes only
RR 1.36 [0.92, 2]
2 studies · 50 participants
Very low