What do systematic reviews say?

Doxycycline 40 mg + azelaic acid gel vs doxycycline 40 mg + metronidazole gel

Doxycycline 40 mg + azelaic acid gel showed no clear difference in proportion of participants with adverse event compared with doxycycline 40 mg + metronidazole gel (high certainty).

• Interventions for rosacea 2015 · Cochrane Headline outcomes only
  RR 0.27 [0.06, 1.28]
  1 study · 207 participants
  High

Doxycycline 40 mg + metronidazole 1% gel vs doxycycline 100 mg + metronidazole 1% gel

Doxycycline 40 mg + metronidazole 1% gel may leads to lower proportion of participants with adverse event compared with doxycycline 100 mg + metronidazole 1% gel (low certainty).

• Interventions for rosacea 2015 · Cochrane Headline outcomes only
  RR 0.25 [0.11, 0.54]
  1 study · 91 participants
  Low

Doxycycline 40 mg vs placebo

• Interventions for rosacea 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 537 participants
  High

Low dose isotretinoin 0.3 mg/kg vs doxycycline

Low dose isotretinoin 0.3 mg/kg showed no clear difference in proportion of participants with adverse event compared with doxycycline 50‐100 mg (high certainty).

• Interventions for rosacea 2015 · Cochrane Headline outcomes only
  RR 1.19 [0.74, 1.92]
  1 study · 299 participants
  High

Azithromycin vs doxycycline

It is very uncertain whether azithromycin changes proportion of participants with adverse event compared with doxycycline 100 mg (very low certainty).

• Interventions for rosacea 2015 · Cochrane Headline outcomes only
  RR 1.62 [0.32, 8.26]
  1 study · 67 participants
  Very low