What do systematic reviews say?

Topical vitamin D derivative vs placebo

Topical vitamin D derivative showed no clear difference in proportion of participants with adverse effects ‐ measured over 8… compared with placebo (moderate certainty).

• Interventions for chronic palmoplantar pustulosis 2020 · Cochrane Headline outcomes only
  RR 0.87 [0.64, 1.19]
  1 study · 188 participants
  Moderate

Puvatherapy vs placebo or no treatment

• Interventions for chronic palmoplantar pustulosis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 22 participants
  Very low

Etretinate vs placebo or no treatment

It is very uncertain whether etretinate changes proportion of participants with adverse effects ‐ measured over 12… compared with placebo or no treatment (very low certainty).

• Interventions for chronic palmoplantar pustulosis 2020 · Cochrane Headline outcomes only
  RR 3.5 [0.95, 12.9]
  1 study · 20 participants
  Very low

Etretinate with PUVA therapy as co‐intervention vs placebo with PUVA therapy

It is very uncertain whether etretinate with PUVA therapy as co‐intervention changes proportion of participants with adverse effects ‐ measured over 20… compared with placebo with PUVA therapy (very low certainty).

• Interventions for chronic palmoplantar pustulosis 2020 · Cochrane Headline outcomes only
  RR 17 [1.11, 259.87]
  1 study · 20 participants
  Very low

Alitretinoin vs placebo

Alitretinoin showed no clear difference in proportion of participants with adverse effects ‐ measured over 24… compared with placebo (moderate certainty).

• Interventions for chronic palmoplantar pustulosis 2020 · Cochrane Headline outcomes only
  RR 0.84 [0.61, 1.17]
  1 study · 33 participants
  Moderate