What do systematic reviews say?

Etretinate vs placebo or no treatment

It is very uncertain whether etretinate changes proportion of participants cleared or almost cleared in the short… compared with placebo or no treatment (very low certainty).

• Interventions for chronic palmoplantar pustulosis 2020 · Cochrane Headline outcomes only
  RR 3.48 [0.82, 14.8]
  2 studies · 40 participants
  Very low