Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews · Pregnancy and Childbirth

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 3 · 50%Moderate 2 · 33.3%High 1 · 16.7%

Vaginal progesterone vs no treatment or placebo

Preterm birth · Women with a multiple pregnancy

Vaginal progesterone showed no clear difference in preterm birth less than 37 weeks compared with no treatment or placebo (moderate certainty).

1 finding from 1 review

Prenatal administration of progestogens for preventing spontaneous preterm birth in women with a multiple pregnancy 2019 · Cochrane Headline outcomes only
RR 0.97 [0.89, 1.06]
6 studies · 1597 participants
Moderate

Vaginal progesterone vs no treatment or placebo

Preterm birth less than 28 weeks · Women with a multiple pregnancy

Vaginal progesterone showed no clear difference in preterm birth less than 28 weeks compared with no treatment or placebo (low certainty).

1 finding from 1 review

Prenatal administration of progestogens for preventing spontaneous preterm birth in women with a multiple pregnancy 2019 · Cochrane Headline outcomes only
RR 1.53 [0.79, 2.97]
3 studies · 1345 participants
Low

Vaginal progesterone vs no treatment or placebo

Preterm birth less than 34 weeks' gestation · Women with a multiple pregnancy

Vaginal progesterone showed no clear difference in preterm birth less than 34 weeks compared with no treatment or placebo (low certainty).

1 finding from 1 review

Prenatal administration of progestogens for preventing spontaneous preterm birth in women with a multiple pregnancy 2019 · Cochrane Headline outcomes only
RR 0.9 [0.66, 1.23]
5 studies · 1503 participants
Low

Intramuscular (IM) progesterone vs no treatment or placebo

Preterm birth less than 34 weeks' gestation · Women with a multiple pregnancy

Intramuscular (IM) progesterone may leads to higher preterm birth less than 34 weeks compared with no treatment or placebo (low certainty).

1 finding from 1 review

Prenatal administration of progestogens for preventing spontaneous preterm birth in women with a multiple pregnancy 2019 · Cochrane Headline outcomes only
RR 1.54 [1.06, 2.26]
2 studies · 399 participants
Low

Intramuscular (IM) progesterone vs no treatment or placebo

Preterm birth less than 28 weeks · Women with a multiple pregnancy

Intramuscular (IM) progesterone showed no clear difference in preterm birth less than 28 weeks compared with no treatment or placebo (moderate certainty).

1 finding from 1 review

Prenatal administration of progestogens for preventing spontaneous preterm birth in women with a multiple pregnancy 2019 · Cochrane Headline outcomes only
RR 1.08 [0.75, 1.55]
5 studies · 1920 participants
Moderate

Intramuscular (IM) progesterone vs no treatment or placebo

Preterm birth · Women with a multiple pregnancy

Intramuscular (IM) progesterone showed no clear difference in preterm birth less than 37 weeks compared with no treatment or placebo (high certainty).

1 finding from 1 review

Prenatal administration of progestogens for preventing spontaneous preterm birth in women with a multiple pregnancy 2019 · Cochrane Headline outcomes only
RR 1.05 [0.98, 1.13]
5 studies · 2010 participants
High